Search results for "genomic region"

showing 3 items of 3 documents

Combined approaches to identify genomic regions involved in phenotypic differentiation between low divergent breeds: Application in Sardinian sheep p…

2019

Selective breeding has led to modifications in the genome of many livestock breeds. In this study, we identified the genomic regions that may explain some of the phenotypic differences between two closely related breeds from Sardinia. A total of 44 animals, 20 Sardinian Ancestral Black (SAB) and 24 Sardinian White (SW), were genotyped using the Illumina Ovine 50K array. A total of 68, 38 and 15 significant markers were identified using the case–control genome-wide association study (GWAS), the Bayesian population differentiation analysis (FST) and the Rsb metric, respectively. Comparisons among the approaches revealed a total of 22 overlapping markers between GWAS and FST and one marker bet…

CoatGenotypePopulationGenome-wide association studygenome-wide methodsBiologySelective breedingGenomePolymorphism Single NucleotideSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoFood Animalsgenome-wide methods; genomic regions; Ovine BeadChip50K; Sardinian sheep breedsSardinian sheep breedsAnimalsGenetic variabilitygenomic regionseducationGeneOvine BeadChip50Keducation.field_of_studySheepHomozygoteMolecular Sequence AnnotationGeneral MedicineGenomicsgenome-wide methodgenomic regionWhite (mutation)PhenotypeEvolutionary biologyAnimal Science and ZoologyJournal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und ZuchtungsbiologieREFERENCES
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Genome-Wide Patterns of Homozygosity Reveal the Conservation Status in Five Italian Goat Populations.

2021

The application of genomic technologies has facilitated the assessment of genomic inbreeding based on single nucleotide polymorphisms (SNPs). In this study, we computed several runs of homozygosity (ROH) parameters to investigate the patterns of homozygosity using Illumina Goat SNP50 in five Italian local populations: Argentata dell’Etna (N = 48), Derivata di Siria (N = 32), Girgentana (N = 59), Maltese (N = 16) and Messinese (N = 22). The ROH results showed well-defined differences among the populations. A total of 3687 ROH segments &gt

Genetic diversityruns of homozygosityGeneral Veterinarygenomic regions.Veterinary medicinePopulation sizeinbreedingSingle-nucleotide polymorphismPhenotypic traitBiologyRuns of Homozygositylocal goat populationBreedArticleGene flowQL1-991Evolutionary biologylocal goat populationsSF600-1100Animal Science and Zoologygenomic regionsZoologyInbreedingGenomic regions; Inbreeding; Local goat populations; Runs of homozygosityAnimals : an open access journal from MDPI
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Genome-wide identification of runs of homozygosity islands and associated genes in local dairy cattle breeds

2018

Runs of homozygosity (ROH) are widely used as predictors of whole-genome inbreeding levels in cattle. They identify regions that have an unfavorable effect on a phenotype when homozygous, but also identify the genes associated with traits of economic interest present in these regions. Here, the distribution of ROH islands and enriched genes within these regions in four dairy cattle breeds were investigated. Cinisara (71), Modicana (72), Reggiana (168) and Italian Holstein (96) individuals were genotyped using the 50K v2 Illumina BeadChip. The genomic regions most commonly associated with ROHs were identified by selecting the top 1% of the single nucleotide polymorphisms (SNPs) most commonly…

Male0301 basic medicineCandidate generuns of homozygosity islandGenotypeRuns of homozygosity islands genomic regions candidate genes local dairy cattle bovine beadchip 50KLocus (genetics)Single-nucleotide polymorphismBiologyRuns of HomozygosityPolymorphism Single NucleotideGenomeSF1-1100bovine beadchip 50K; candidate genes; genomic regions; local dairy cattle; runs of homozygosity islands; Animal Science and ZoologySettore AGR/17 - Zootecnica Generale E Miglioramento Genetico03 medical and health sciencesAnimalsInbreedinggenomic regionsGeneDairy cattleGeneticslocal dairy cattleGenomeReproductionHomozygote0402 animal and dairy sciencecandidate gene04 agricultural and veterinary sciences040201 dairy & animal sciencegenomic regionAnimal cultureruns of homozygosity islandsDairyingPhenotype030104 developmental biologybovine beadchip 50KCattleFemaleAnimal Science and Zoologycandidate genesInbreeding
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